The HiREB provides a mechanism for approval for the purpose of submission to granting agencies. This is not permission to begin research. The HiREB Chair, or his/her delegate, determines whether or not there are ethical issues which could prevent the project from receiving approval by the full REB. If so, then presentation before the REB is required. If not, in-principle approval can be granted. Once funding for the project is approved, then the project must be brought to the full REB for review.